Asymmetric Synthesis of Mercaptoalcohols - Matrix Metalloproteinase Inhibitors
- 1 September 1999
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1999 (9) , 1371-1374
- https://doi.org/10.1055/s-1999-2858
Abstract
A novel approach has been developed for the preparation of all of the possible diastereoisomers of mercaptoalcohol 1, a potent matrix metalloproteinase (MMP) inhibitor, with easy access to various P1′ substituents. Readily available chiral epoxides have been used as the starting materials to control the stereochemistry of the -OH group.Keywords
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