CEREBRAL BLOOD FLOW AND METABOLISM DURING ETOMIDATE ANAESTHESIA IN MAN
Open Access
- 1 October 1978
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 50 (10) , 1047-1051
- https://doi.org/10.1093/bja/50.10.1047
Abstract
The effects of etomidate on regional cerebral blood flow (rc.b.f.) and cerebral metabolic rate for oxygen (CMRo2) were studied in seven patients undergoing diagnostic carotid angiography. Following determination of baseline rc.b.f. while awake, the patients were anaesthetized with a single dose of etomidate 15 mg. Thereafter an infusion of etomidate (2 or 3 mg min–1) was administered. Etomidate decreased both rc.b.f.10 (mean decrease 34%) and CMRo2 (mean decrease 45%). It was concluded that etomidate is a potent cerebral metabolic depressant. Furthermore, the cerebrovascular reactivity to carbon dioxide was maintained under etomidate anaesthesia.This publication has 4 references indexed in Scilit:
- RESPIRATORY EFFECTS OF ETOMIDATEBritish Journal of Anaesthesia, 1977
- Arterial Pco2 and cerebral hemodynamicsAmerican Journal of Physiology-Legacy Content, 1964
- Regional Cerebral Blood Flow Measurement in ManArchives of Neurology, 1963
- CEREBRAL CIRCULATION AND METABOLISM DURING THIOPENTAL ANESTHESIA AND HYPERVENTILATION IN MAN*Journal of Clinical Investigation, 1962