Rubella Booster Immunization

Publisher Website
Google Scholar
Abstract
To determine the persisting effect on base-line antibody levels of a booster dose of rubella vaccine, blood specimens were obtained eight to ten weeks following revaccination from 92 study children immunized initially in July 1968. Only six of 92 (6.5%) revaccinees demonstrated a fourfold or greater rise in rubella hemagglutination-inhibiting (HI) antibody titer. The HI titers before administration of the booster dose were low in all six (1:32 or less); however, similar low titers were noted in 33 revaccinees who demonstrated no increase in antibody. These data suggest that a second dose of rubella vaccine given approximately two years following primary immunization does not significantly increase antibody levels and, therefore, may be ineffective in enhancing resistance to reinfection.

This publication has 5 references indexed in Scilit: