Altered Angiotensin-II Receptors in Human Hepatocellular and Hepatic Metastatic Colon Cancers

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Abstract
To characterize angiotensin-II receptor density and affinity in normal and cirrhotic livers and in hepatocellular and metastatic colorectal cancer. Summary Background Data studies have indicated a possible beneficial effect of angiotensin-II as a biologic response modifier in the treatment of hepatic or metastatic colon cancer. This is based on evidence that angiotensin-II will cause a selective increase in arterial vasoconstriction in normal liver compared with tumor. Human hepatoma (5), metastatic colon (10), or cirrhotic (3) liver was obtained. Non-tumor-bearing regions served as normal liver. Angiotensin-II receptor binding was determined on membranes with 125l-angiotensin-ll and in situ studies were performed using the biotin-avidin detection system. Results-II receptor density was markedly down-regulated in tumor compared with normal or cirrhotic liver. Conclusions loss of angiotensin-II receptors occurs on the neovasculature of hepatic tumors.