Histopathological Findings in Clinical Gentamicin Ototoxicity
- 1 February 1982
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery
- Vol. 108 (2) , 65-70
- https://doi.org/10.1001/archotol.1982.00790500001001
Abstract
• The temporal bone histopathological findings in a case of gentamicin sulfateinduced hearing loss and vertigo in an anephric patient undergoing hemodialysis are presented. A study of the sensory neuroepithelium of the cristae and maculae disclosed the presence of vacuoles with clubbing of the sensory cells. In the cochlea, loss of the innermost row of outer hair cells in the basal turn was the most prominent feature. These findings are discussed in light of reports of similar morphological changes in laboratory studies of gentamicin ototoxicity. (Arch Otolaryngol 1982;108:65-70)This publication has 7 references indexed in Scilit:
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