Mitochondrial Calcium Homeostasis: Mechanisms and Molecules

Open Access
Publisher Website
Google Scholar
Abstract
Despite the early characterisation of Ca 2+ fluxes in isolated mitochondria and the ability of this ion to up‐regulate dehydrogenases of the Krebs cycle, the low affinity of the organelle uptake pathways was a long‐standing obstacle to the recognition of a physiological role for mitochondrial Ca 2+ uptake. This review begins with a historical account of the main results that proved the contrary and provides a brief description of mitochondrial Ca 2+ signals. Then, it discusses the characteristics of Ca 2+ regulation of mitochondrial function. Finally, it summarizes recent discoveries on structural aspects of mitochondrial reticulum and its connections to signalling partners such as the endoplasmic reticulum or the plasma membrane.

This publication has 0 references indexed in Scilit: