Generation of an Apoptotic Intracellular Peptide by γ-Secretase Cleavage of Alzheimer's Amyloid ß Protein Precursor

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Abstract
The amyloid ß protein precursor (AßPP) is sequentially processed by ß- and γ-secretases to generate the Aß peptide. The biochemical path leading to Aß formation has been extensively studied since extracellular aggregates of amyloidogenic forms of Aß

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