Differences in Chromosome Stem-lines of a Strain of HeLa Cells Inhibited in Growth by Certain Steroids, and of Steroid-Resistant Sub-lines Selected from the Sensitive Strain
- 1 August 1962
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 71 (2) , 238-243
- https://doi.org/10.1210/endo-71-2-238
Abstract
Chromosome numbers have been studied in a HeLa cell population sensitive to the inhibitory influences of desoxycorticosterone and testosterone (strain HuE) and in its sub-lines d and t resistant to desoxycorticosterone and testosterone, respectively. It has been found that strain HuE has a stem line of 68 chromosomes, while both the steroid- resistant sub-lines exhibit stem lines of 74. The data suggest that steroid “resistancy” in the cell strain and sub-lines is due to more subtle variations than a net increase of 6 chromosomes.Keywords
This publication has 3 references indexed in Scilit:
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- GENETICS OF SOMATIC MAMMALIAN CELLSThe Journal of Experimental Medicine, 1958
- Comparative Chromosomal Studies on Mammalian Cells in Culture. I. The HeLa Strain and Its Mutant Clonal Derivatives23JNCI Journal of the National Cancer Institute, 1958