Oligopeptide Mapping of NP Proteins of Influenza A Viruses

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Abstract
Oligopeptide mapping of nucleoproteins (NP proteins) of 54 strains of influenza A virus showed the presence of both common and individual oligopeptides. Using the distribution of variable oligopeptides as the criterion, NP proteins were subdivided into 4 groups (NP0 , NP1, NP2 and NP3). The NP0 group is composed of H0N1 influenza viruses and the majority of animal influenza viruses. The NP1 group contains H1N1 (except A/California/78) and H2N2 influenza viruses isolated from man and H1N1 influenza viruses recently isolated from animals. A/New Jersey/76 (Hsw1N1) influenza virus also belongs to the NP1 group. The NP2 group consists of H3N2 influenza viruses isolated from man and animals. A/California/78 (H1N1) influenza virus also falls into the NP2 group. The NP3 group contains NP proteins of 4 animal influenza viruses with the antigenic formulas Hsw1N2, Hsw1Nav2, Hav6Nav5 and Heq2Neq2.