Studies on Coumarins of a Chinese Drug “Qian-Hu”; VII1. Structures of New Coumarin-Glycosides of Zi-Huan Quian-Hu and Effect of Coumarin-Glycosides on Human Platelet Aggregation

Publisher Website
Google Scholar
Abstract
Three kinds of new coumarin-glycosides, decuroside I (1), decuroside II (2), decuroside III (3), which were isolated from the n-butanol extracts of the crude drug Zi-Hua Qian-Hu, the root of Peucedanum decursivum Maxim. (Umbelliferae), were elucidated to be nodakenetin-4′-O-β-gentiobiose, nodakenetin-4′-Oβ-isomaltose and nodakenetin-4′-O-β-maltose, respectively, by the methods of chemical and spectral analysis. These three new compounds as well as decuroside IV (4), decuroside V (5) and nodakenin (6) which were also isolated from Zi-Hua Qian-Hu were tested on human platelet aggregation induced by 2 µM ADP. Among these coumarin-glycosides, 3 and 4, showed the strongest inhibiting activity against the primary and secondary wave aggregation of human platelet. 1 and 2 had a less inhibiting effect or none at all, and 5 was rather promotive against the primary wave aggregation.

This publication has 0 references indexed in Scilit: