PROGESTERONE-LIKE ACTIVITY OF SOME STEROID COMPOUNDS AND OF DIETHYLSTILBESTROL IN STIMULATING MAMMARY LOBULE-ALVEOLAR GROWTH1,2
- 1 May 1942
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 30 (5) , 706-710
- https://doi.org/10.1210/endo-30-5-706
Abstract
Desoxycorticosterone acetate, dehydroandrosterone, diethylstilbestrol, acetoxypregneninolone, methyl testosterone, testosterone and testosterone propionate were assayed and compared with progesterone for their ability to stimulate mammary lobule-alveolar growth in the ovariec-tomized [female] mouse. Using progesterone as a standard, pregneninolone had an activity of approx. 1/2, desoxycorticosterone acetate and dehydroandrosterone of 1/3, diethylstilbestrol of 1/4, acetoxy-pregneninolone of 1/16, and methyl testosterone of 1/25, that of progesterone. Testosterone and testosterone propionate in doses up to 10 mg. failed to stimulate lobule-alveolar growth.This publication has 4 references indexed in Scilit:
- On The Hormonal Activity of a Steroid CompoundScience, 1941
- PROGESTATIONAL ACTION OF DESOXYCORTICOSTERONE ACETATE IN SPAYED-ADRENALECTOMIZED CATS1,2,3Endocrinology, 1940
- The progesterone-like action of testosterone and certain related compoundsProceedings of the Royal Society of London. B. Biological Sciences, 1937
- The Relation Between the Estrus-Producing Hormone and a Corpus Luteum Extract on the Growth of the Mammary GlandScience, 1931