Rauscher Virus Infection, Erythrocyte Clearance Studies, and Autoimmune Phenomena2

Publisher Website
Google Scholar
Abstract
Mice infected with high doses of Rauscher virus (RV) developed the typical prelymphoid leukemic disease characterized by hemolytic anemia and thrombocytopenia. Survival times of 51Cr-labeled erythrocytes from normal syngeneic mice were significantly shorter in RV-infected mice than in uninfected controls. In vitro tests showed that serum factors were not responsible for the shortened erythrocyte survival times. Spleen lymphocytes, but not peripheral blood lymphocytes, from RV-infected mice were stimulated into DNA synthesis by erythrocytes from both RV-infected and uninfected mice. We suggest that spleen lymphocytes from RV-infected mice made an immune response against erythrocytes from both uninfected and RV-infected mice. The spleen lymphocytes did not respond to erythrocytes from sheep and, compared with spleen lymphocytes from normal mice, showed a decreased response to phytohemagglutinin (PHA). However, this decrease was counterbalanced by the increase in PHA-responsive cells in the peripheral blood.

This publication has 0 references indexed in Scilit: