Faculty Opinions recommendation of Epigenetic differences arise during the lifetime of monozygotic twins.

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Abstract
In spite of all their similarities, monozygotic (MZ) twins present intriguing differences, such as in their susceptibility to psychiatric diseases. From where do these differences originate? This paper examines the occurrence of epigenetic differences between MZ twins and reveals that patterns of DNA methylation and histone acetylation diverge increasingly with age and with differences in lifestyle and environment. The result suggests that random or environment-dependent variations in the epigenetic control of gene expression may be an important factor in determining individual responses to a given genetic background, and may have wide implications in human genetics, in animal cloning or in the analysis of mental diseases.

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