Coronaviruses: Important Emerging Human Pathogens
Top Cited Papers
Open Access
- 15 May 2014
- journal article
- review article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 88 (10) , 5209-5212
- https://doi.org/10.1128/jvi.03488-13
Abstract
Infections with high-risk human papillomaviruses (hrHPV) contribute to cervical carcinoma. The cdk inhibitor and tumor suppressor p16INK4A is consistently upregulated in cervical carcinoma cells for reasons that are poorly understood. We report here that downregulation of p16INK4A gene expression in three different cervical carcinoma cell lines reduced expression of the E7 oncogene, suggesting a positive feedback loop involving E7 and p16INK4A. p16INK4A depletion induced cellular senescence in HeLa but not CaSki and MS-751 cervical carcinoma cells.Keywords
This publication has 18 references indexed in Scilit:
- Middle East Respiratory Syndrome Coronavirus Spike Protein Delivered by Modified Vaccinia Virus Ankara Efficiently Induces Virus-Neutralizing AntibodiesJournal of Virology, 2013
- Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaquesProceedings of the National Academy of Sciences, 2013
- Receptor-binding domain as a target for developing SARS vaccines2013
- The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Does Not Replicate in Syrian HamstersPLOS ONE, 2013
- Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in HumansmBio, 2012
- Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi ArabiaNew England Journal of Medicine, 2012
- A review of studies on animal reservoirs of the SARS coronavirusVirus Research, 2008
- Molecular Evolution Analysis and Geographic Investigation of Severe Acute Respiratory Syndrome Coronavirus-Like Virus in Palm Civets at an Animal Market and on FarmsJournal of Virology, 2005
- Antibodies to SARS Coronavirus in CivetsEmerging Infectious Diseases, 2004
- Molecular Evolution of the SARS Coronavirus During the Course of the SARS Epidemic in ChinaScience, 2004