Either Orientation of the L Segment of the Herpes Simplex Virus Genome May Participate in the Production of Viable Intertypic Recombinants
Open Access
- 1 January 1983
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 64 (1) , 247-250
- https://doi.org/10.1099/0022-1317-64-1-247
Abstract
We have analysed the genome structures of 90 recombinant viruses produced by co-infection of baby hamster kidney cells with the DNA of a herpes simplex virus type 1 temperature-sensitive mutant (tsD) and specific DNA fragments of wild-type herpes simplex virus type 2 at non-permissive temperature. Crossovers were located predominantly in regions of greatest intertypic homology, and we conclude that primary recombination occurred with the L segment of the genome in either orientation.Keywords
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