Testing challenges: evaluation of novel diagnostics and molecular biomarkers
Open Access
- 1 February 2009
- journal article
- Published by Elsevier in Clinical Medicine
- Vol. 9 (1) , 68-73
- https://doi.org/10.7861/clinmedicine.9-1-68
Abstract
Through the lens of public health genomics, this article probes certain issues that concern the evaluation of diagnostic tests and molecular biomarkers, and the accompanying policy and regulatory implications. It begins with some conceptual remarks followed by a discussion of evaluation, translation, and regulation, and their importance for public health.Keywords
This publication has 13 references indexed in Scilit:
- Polygenes, Risk Prediction, and Targeted Prevention of Breast CancerNew England Journal of Medicine, 2008
- A Critical Appraisal of the Scientific Basis of Commercial Genomic Profiles Used to Assess Health Risks and Personalize Health InterventionsAmerican Journal of Human Genetics, 2008
- Translation 2 ResearchAmerican Journal of Preventive Medicine, 2007
- The in-between world of knowledge brokeringBMJ, 2007
- Association Analysis of 6,736 U.K. Subjects Provides Replication and Confirms TCF7L2 as a Type 2 Diabetes Susceptibility Gene With a Substantial Effect on Individual RiskDiabetes, 2006
- Translational and Clinical Science — Time for a New VisionNew England Journal of Medicine, 2005
- Ensuring the appropriate use of genetic testsNature Reviews Genetics, 2004
- Limitations of the Odds Ratio in Gauging the Performance of a Diagnostic, Prognostic, or Screening MarkerAmerican Journal of Epidemiology, 2004
- Will Genetics Revolutionize Medicine?New England Journal of Medicine, 2000
- Evolution, Population Thinking, and EssentialismPhilosophy of Science, 1980