Influence of the route of administration on the toxicity of some cholinesterase inhibitors
- 1 September 1967
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 19 (9) , 612-616
- https://doi.org/10.1111/j.2042-7158.1967.tb09598.x
Abstract
The acute median lethal doses of a series of cholinesterase inhibitors have been estimated in mice for different routes of administration Differences in the LD50 values obtained for intraperitoneal and oral routes (“hepatic” routes) and subcutaneous and intravenous routes (“peripheral” routes) suggest that the availability of the compound for metabolism by the liver is a major factor in their toxicity.This publication has 7 references indexed in Scilit:
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