Calcium channels in undifferentiated PC12 rat pheochromocytoma cells
- 25 September 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 255 (2) , 398-400
- https://doi.org/10.1016/0014-5793(89)81131-7
Abstract
Undifferentiated rat pheochromocytoma PC12 cells were voltage clamped using the whole cell technique. After blockade of outward currents, calcium currents were elicited from −40 and −100 mV. A subpopulation of cells displayed only one current component activated at −10 mV and slowly decaying. In other cells this current coexisted with a component activated around −40 mV and decaying with a faster time constant. We conclude that undifferentiated PC12 cells can express two types of calcium channels, L (long-lasting) and N (neuronal)-type channels.Keywords
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