The effect of carrageenan-induced inflammation on the sensitivity of unmyelinated skin nociceptors in the rat

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Abstract
Exhibited spontaneous activity; their mechanical thresholds (von Frey) were higher than those of not spontaneously active fibers. None of the units located outside of the inflamed area displayed sensitization. The data reveal that only part of the CMH units in a uniformly inflamed skin area shows signs of sensitization. Our results are compared to those obtained in other inflammatory processes. The relation to inflammatory pain and to hyperalgesia and the contribution of endogenous substances to sensitization of CMH units are discussed. *Correspondence to: Dr. L. Kocher, Laboratoire de Physiologie, Faculté de Médecine Lyon-Sud, Chemin du Petit Revoyet B.P. 12, F-69921 Oullins,CedexFrance. (Received 25 July 1986; revised received 13 November 1986; accepted 18 November 1986.( © Lippincott-Raven Publishers....