Lack of an Effect of Saline Loading on Glycerol-Induced Acute Renal Failure

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Abstract
To determine whether saline loading actually protects against acute renal failure, both Gn and BUN were measured in rats drinking either tap water or 1% saline for 1–3 months. At 24 and 48 h after an injection of 10 ml/kg i.m. of 50% glycerol in water, Gn was equally reduced in saline-drinking and water-drinking rats as compared to uninjected rats. The daily intraperitoneal injection of saline for 1–3 months also was not protective. At 48 hours after glycerol injection, the BUN concentration in saline-drinking rats was significantly lower than in water-drinking rats. This was probably due to the greater renal urea clearance in these animals. We conclude from these findings that saline loading does not protect against glycerol-induced acute renal failure in the rat although it affects the Curea and BUN concentration.