Synthesis and Biological Activity of Enantiomeric Oxapenemcarboxylic Acids
- 1 January 1992
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1992 (11) , 1179-1184
- https://doi.org/10.1055/s-1992-26329
Abstract
The synthesis of enantiomerically pure potassium (5R)- and (5S)-trans-2-tert-butyl-6-hydroxymethyloxapenem-3-carboxylates is reported. Surprisingly, both enantiomers were active antibiotics and ß-lactamase inhibitors.Keywords
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