Calcium-dependent potassium current following penicillin-induced epileptiform discharges in the hippocampal slice
- 1 December 1989
- journal article
- research article
- Published by Springer Nature in Experimental Brain Research
- Vol. 78 (3) , 646-648
- https://doi.org/10.1007/bf00230253
Abstract
Penicillin-induced paroxysmal depolarization shifts (PDS) are followed by prolonged afterhyperpolarizations of about 2 seconds duration. Intracellular injection of EGTA blocked a late component of the afterhyperpolarizations; an early one lasting up to one second was only slightly reduced by EGTA. It is concluded that afterhyperpolarizations following penicillininduced PDS comprise different components: an initial one lasting up to one second which is not Ca2+-dependent and a slow one lasting up to two seconds which is caused by a Ca2+-dependent K+ current.Keywords
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