A stereoselective synthesis of a stable prostacyclin analogue ; dl-3-Oxa-9(O)-methano-.DELTA.6(9.ALPHA.)-prostaglandin I1.
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (3) , 948-956
- https://doi.org/10.1248/cpb.35.948
Abstract
A prostacyclin analogue, dl-3-oxa-9(O)-methano-.DELTA.6(9.alpha.)-prostaglandin I1 (1a), has been synthesized. The key step for this synthesis is a new, one-step conversion reaction of the (hydroxy-methyl)cyclopropylketone group in 8 and 21 to the .gamma.,.delta.-unsaturated ketone 9 and 22, respectively, with iodotrimethylsilane.This publication has 3 references indexed in Scilit:
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- Synthesis of -4,5,6-trinor-3,7-inter--phenylene-3-oxaprostaglandins including one which inhibits platelet aggregationProstaglandins, 1975