Gametocytogenesis ofPlasmodium falciparum in vitro:ultrastructural observations on the lethal action of chloroquine
- 31 January 1982
- journal article
- research article
- Published by Taylor & Francis in Pathogens and Global Health
- Vol. 76 (1) , 15-23
- https://doi.org/10.1080/00034983.1982.11687500
Abstract
Immature gametocytes (stages I—III) of Plasmodium falciparum are readily killed by chloroquine at a concentration of 0·1 nmol ml−1. The morphological effects of this drug at the ultrastructural level appear very similar to those described previously for the asexual parasites. Lesions were classified into four groups, disorganization of food vacuole; pellicular modifications; mitochondrial changes, and nuclear modifications. The timing and sequence of development of these lesions strongly suggest that the drug acts quickly through disruption of food vacuole activity with consequent secondary metabolic effects. Direct effects on the parasites' chromatin are considered unlikely for nuclear division was frequently recorded in grossly distorted cells.This publication has 15 references indexed in Scilit:
- Gametocytogenesis of Plasmodium falciparum in vitro: the cell-cycleParasitology, 1979
- Gametocyte and gamete development inPlasmodium falciparumProceedings of the Royal Society of London. B. Biological Sciences, 1978
- Plasmodium falciparum gametocytes: their longevity and infectivityParasitology, 1977
- Incorporation of Radioactive Precursors into DNA and RNA of Plasmodium knowlesi in vitroThe Journal of Protozoology, 1970
- Infectivity of Chloroquine Resistant Plasmodium berghei to Anopheles stephensi enhanced by ChloroquineNature, 1969
- Morphological Effects of Chloroquine on Plasmodium berghei in MiceNature, 1967
- Morphologic Observations on the Effect of Antimalarial Agents on the Erythrocytic Forms of Plasmodium Berghei in VitroMilitary Medicine, 1966
- Studies on Modes of Action of Chloroquine, Quinacrine, and Quinine and on Chloroquine ResistanceMilitary Medicine, 1966
- A study of gametocytes in a west african strain of plasmodium falciparumTransactions of the Royal Society of Tropical Medicine and Hygiene, 1951
- Observations on the action of quinine, atebrin and plasmoquine on the gametocytes of Plasmodium falciparumTransactions of the Royal Society of Tropical Medicine and Hygiene, 1949