The Cellular Basis of Site-Specific Tumor Metastasis

Publisher Website
Google Scholar
Abstract
THE year 1989 marked the 100th anniversary of the publication of a seminal paper in the study of the biology of human tumors. Stephen Paget, having collected the autopsy records of 735 patients who died of breast cancer, noted that the majority of the metastatic lesions were found in the liver and brain, whereas other organs, such as the kidney and spleen, were much less frequently involved. Paget inferred from this observation that certain tumors were predisposed to spread to particular tissues, on the basis of the tissue's ability to support the growth of these tumors.1 He likened this process . . .