Effect of ADP/ATP antiporter conformational state on the suppression of the nonspecific permeability of the inner mitochondrial membrane by cyclosporine A
- 17 December 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 277 (1-2) , 123-126
- https://doi.org/10.1016/0014-5793(90)80824-3
Abstract
The influence of the conformational state of ADP/ATP antiporter on the efficiency of the inhibitory effect of cyclosporine A on the Ca2+‐induced nonspecific permeability of the inner mitochondrial membrane has been studied. Carboxyatractiloside, the inhibitor of ADP/ATP‐antiporter, was shown to prevent the cyclosporine A‐induced suppression of the nonspecific permeability. The Carboxyatractiloside enect was displayed only in mitochondria depleted of adenine nucleotides. Bifunctional SH reagent, phenylarsine oxide, was also able to reverse the effect of cyclosporine A. The data are consistent with the suggestion that cyclosporine A causes suppression of the nonspecific permeability due to its effect on the ADP/ATP antiporter conformation.Keywords
This publication has 11 references indexed in Scilit:
- Relationships between the NAD(P) redox state, fatty acid oxidation, and inner membrane permeability in rat liver mitochondriaArchives of Biochemistry and Biophysics, 1989
- Involvement of the ADPATP carrier in calcium-induced perturbations of the mitochondrial inner membrane permeability: Importance of the orientation of the nucleotide binding siteArchives of Biochemistry and Biophysics, 1988
- Action of cyclosporine on mitochondrial calcium fluxesJournal of Bioenergetics and Biomembranes, 1987
- Characterization of pyrophosphate exchange by the reconstituted adenine nucleotide translocator from mitochondriaBiochemical and Biophysical Research Communications, 1985
- On the mechanism by which Mg2+ and adenine nucleotides restore membrane potential in rat liver mitochondria deenergized by Ca2+ and phosphateBiochemical and Biophysical Research Communications, 1983
- Mitochondrial coupling factor B: Properties and role in ATP synthesisBiochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1982
- In vitro alteration of the size of the liver mitochondrial adenine nucleotide pool: Correlation with respiratory functionsArchives of Biochemistry and Biophysics, 1980
- The Ca2+-induced membrane transition in mitochondriaArchives of Biochemistry and Biophysics, 1979
- Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady stateThe Journal of Membrane Biology, 1979
- [15] Isolation of liver or kidney mitochondriaPublished by Elsevier ,1967