RESIDENCE TIME AND ACCUMULATION OF DRUGS IN THE BODY
- 1 January 1981
- journal article
- research article
- Vol. 19 (2) , 82-85
Abstract
A simple and clinically useful theory of drug accumulation based on the mean residence time of drug molecules in the plasma compartment is presented. The parameters decay fraction and accumulation factor, defined in terms of average steady-state amount in the body, are used to characterize the pharmacokinetics of multiple dosing. These parameters are calculated for digoxin and digitoxin [using data obtained in humans].This publication has 3 references indexed in Scilit:
- Pharmacokinetic model based on circulatory transportEuropean Journal of Clinical Pharmacology, 1979
- Linear pharmacokinetic equations allowing direct calculation of many needed pharmacokinetic parameters from the coefficients and exponents of polyexponential equations which have been fitted to the dataJournal of Pharmacokinetics and Biopharmaceutics, 1976
- Volume of Distribution as a Function of TimeJournal of Pharmaceutical Sciences, 1976