NEODYMIUM-YTTRIUM ALUMINUM GARNET LASER DESTRUCTION OF NONSENSITIZED AND HEMATOPORPHYRIN DERIVATIVE-SENSITIZED TUMORS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 43  (6) , 2876-2879
Abstract
The injection of hematoporphyrin derivative (5 mg/kg i.v.) followed 24 h later by a neodymium-yttrium aluminum garnet (Nd-YAG) laser irradiation shows the destruction of [human colon adenocarcinoma] CX1 tumors grafted on nude mice. This acidophilic necrosis occurred with a significantly increased frequency in tumors treated by hematoporphyrin derivative injection and irradiated with the Nd-YAG laser as compared with noninjected but irradiated tumors or with injected tumors irradiated with sunlight. Based on the data, it seems difficult to maintain the hypothesis of singlet oxygen production as the only mechanism of the phenomenon. Further studies will be necessary to explain the necrosis.