A preliminary study of possible psychoactive effects of intravenous forskolin in depressed and schizophrenic patients
- 1 December 1996
- journal article
- clinical trial
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 103 (12) , 1463-1467
- https://doi.org/10.1007/bf01271261
Abstract
Summary Forskolin is a unique activator of adenylate cyclase that bypasses membrane receptors and directly raises levels of the second messenger cyclic AMP. Depressed patients and schizophrenic patients with negative symptoms have been reported to have reduced cyclic AMP levels. In the first study of forskolin in psychiatry, we gave iv forskolin in a 75 minute infusion to four depressed and five schizophrenic patients. All four depressed patients showed a transient mood elevation or stimulation, as did two of the five schizophrenic patients.Keywords
This publication has 16 references indexed in Scilit:
- The effect of acute and chronic lithium on forskolin-induced reduction of rat activityJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1997
- Adenosine receptors of human leukocytes—IIBiochemical Pharmacology, 1990
- Cardiovascular Effects of Forskolin (HL 362) in Patients with Idiopathic Congestive Cardiomyopathy—A Comparative Study with Dobutamine and Sodium NitroprussideJournal of Cardiovascular Pharmacology, 1990
- Dysbalance of neuronal second messenger function in the aetiology of affective disorders: A pathophysiological concept hypothesising defects beyond first messenger receptorsJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1989
- Lack of effectiveness of forskolin or inositol as antidote in lithium toxicityJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1988
- Effects of forskolin on spontaneous behavior, rectal temperature and brain cAMP levels of rats: interaction with rolipramNeuroscience Letters, 1987
- CLINICAL STUDIES OF VASOPRESSIN IN LEARNING DISORDERSClinical Neuropharmacology, 1984
- Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.Proceedings of the National Academy of Sciences, 1981
- Amphetamine Effects in Man: Paradoxical Drowsiness and Lowered Electrical Brain Activity (CNV)Science, 1974
- Urinary Excretion of Cyclic Amp and Manic-Depressive PsychosisThe British Journal of Psychiatry, 1972