Hydrophobicity of several rhodium(II) carboxylates correlated with their biologic activity
- 1 July 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (7) , 943-946
- https://doi.org/10.1021/jm00217a016
Abstract
Rhodium(II) carboxylates differ greatly in antitumor activity and toxicity depending on the properties of the carboxylate group (methoxyacetate, propionate, butyrate, etc.) involved. The solubility characteristics of rhodium(II) carboxylates correlate well with the antitumor activity and toxicity that these compounds display. The amount of Rh adsorbed by tumor cells in vitro also correlates with the partition coefficient of the Rh(II) compounds studied. Survival and toxicity studies show Rh(II) pentanoate to possess the highest therapeutic index against the Ehrlich ascites mouse tumor strain and also show that lengthening the carboxylate R chain beyond the pentanoate reduces the drugs'' therapeutic efficacy.This publication has 0 references indexed in Scilit: