Treatment of X-Linked Severe Combined Immunodeficiency by in Utero Transplantation of Paternal Bone Marrow
- 12 December 1996
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 335 (24) , 1806-1810
- https://doi.org/10.1056/nejm199612123352404
Abstract
Severe combined immunodeficiency is a congenital syndrome due to various genetic abnormalities that cause susceptibility to infection, failure to thrive, lymphoid hypoplasia, very low levels of T lymphocytes, and hypogammaglobulinemia.1,2 Untreated, the disorder is usually fatal within the first year of life. We report the successful treatment of a fetus with the X-linked variant of severe combined immunodeficiency by the in utero transplantation of paternal bone marrow that was enriched with hematopoietic cell progenitors.Keywords
This publication has 22 references indexed in Scilit:
- Female germ line mosaicism as the origin of a unique IL-2 receptor gamma-chain mutation causing X-linked severe combined immunodeficiency.Journal of Clinical Investigation, 1995
- In vitro analysis of metabolic predisposition to drug hypersensitivity reactionsClinical and Experimental Immunology, 1995
- High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.The Journal of Experimental Medicine, 1994
- In utero transplantation of hematopoietic stem cellsCritical Reviews in Oncology/Hematology, 1993
- The interleukin-2 receptor γ chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1Human Molecular Genetics, 1993
- Engraftment and long-term expression of human fetal hemopoietic stem cells in sheep following transplantation in utero.Journal of Clinical Investigation, 1992
- In utero transplantation of hematopoietic stem cells in sheep: The role of T cells in engraftment and graft-versus-host diseaseJournal of Pediatric Surgery, 1990
- Prenatal Test for X-Linked Severe Combined Immunodeficiency by Analysis of Maternal X-Chromosome Inactivation and Linkage AnalysisNew England Journal of Medicine, 1990
- Early events in human T cell ontogeny. Phenotypic characterization and immunohistologic localization of T cell precursors in early human fetal tissues.The Journal of Experimental Medicine, 1988
- Activation of T lymphocytes by immobilized monoclonal antibodies to CD3. Regulatory influences of monoclonal antibodies to additional T cell surface determinants.Journal of Clinical Investigation, 1988