Towards unravelling the Igf2/H19 imprinted domain
- 1 October 1995
- Vol. 17 (10) , 835-838
- https://doi.org/10.1002/bies.950171004
Abstract
Genomic imprinting is an epigenetic marking process that confers parent‐of‐origin‐dependent expression on certain genes. These imprinted genes are sometimes found in clusters, suggesting a possible involvement of higher order regulatory elements controlling expression and imprinting of genes organised in such clusters. In the distal chromosome 7 there are at least four imprinted genes: Mash2, Ins2, Igf2 and H19. Recent evidence(1) suggests that imprinting and expression of at least Igf2 and H19 may be mechanistically linked.Keywords
This publication has 23 references indexed in Scilit:
- Inherited microdeletions in the Angelman and Prader–Willi syndromes define an imprinting centre on human chromosome 15Nature Genetics, 1995
- Comparative Analysis of Igf-2/H19 Imprinted Domain: Identification of a Highly Conserved Intergenic DNase I Hypersensitive RegionGenomics, 1994
- Allelic methylation of H19 and IGF2 in the Beckwith — Wiedemann syndromeHuman Molecular Genetics, 1994
- Role for DNA methylation in genomic imprintingNature, 1993
- Constitutional relaxation of insulin–like growth factor II gene imprinting associated with Wilms' tumour and gigantismNature Genetics, 1993
- Physical linkage of two mammalian imprinted genes, H19 and insulin–like growth factor 2Nature Genetics, 1992
- Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityPublished by Elsevier ,1992
- Embryological and molecular investigations of parental imprinting on mouse chromosome 7Nature, 1991
- Parental imprinting of the mouse H19 geneNature, 1991
- DIFFERENTIAL IMPRINTING AND EXPRESSION OF MATERNAL AND PATERNAL GENOMESAnnual Review of Genetics, 1988