PULMONARY SPOROTRICHOSIS - TREATMENT WITH MICONAZOLE
- 1 January 1976
- journal article
- research article
- Published by Elsevier
- Vol. 114 (2) , 403-406
- https://doi.org/10.1164/arrd.1976.114.2.403
Abstract
I.v. miconazole, an investigational, broad-spectrum, antifungal imidazole drug, was clinically effective when used for the 1st time in a patient with life-threatening sporotichosis. Miconazole was used after drug resistance and treatment failure occurred in a patient with extensive, cavitary, pulmonary infection with Sporotrichum schenckii. He was 1st treated with amphotericin B, and then with amphotericin B and flucytosine in combination. Side effects of miconazole included itching, diarrhea and phlebitis. Clinical improvement occurred despite plasma concentrations below those needed for complete inhibition of the patient''s organisms in vitro.This publication has 2 references indexed in Scilit:
- Synergism of Amphotericin B with Other Antimicrobial AgentsAnnals of Internal Medicine, 1973
- Systemic SporotrichosisAnnals of Internal Medicine, 1970