Hypersensitivity of in vitro myasthenic muscle to d‐tubocurarine

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Abstract
The response of an in vitro preparation of intercostal muscle from a myasthenic patient after the preparation was subjected to varying doses of d-tubocurarine chloride has been described. A comparison is made between this response and that shown by nonmyasthenic muscle. The results seem to show that the defect in neuromuscular transmission in myasthenic muscle is probably due to some change at the neuromuscular junction itself.