1-Aminoalkanephosphonates. Part II. A Facile Conversion of 1-Aminoalkanephosphonic Acids into 0,0-Diethyl 1-aminoalkanephosphonates
- 1 January 1997
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1997 (01) , 44-46
- https://doi.org/10.1055/s-1997-1508
Abstract
1-(N-Trifluoroacetylamino)alkanephosphonate 0,0-diethyl esters 2 C, obtained from parent 1-aminoalkanephosphonic acids 1, have been selectively deprotected on the amino function affording 0,0-diethyl 1-aminoalkanephosphonates 3. Protonation constants of all amino esters 3 synthesized have been determined by potentiometric titration.Keywords
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