THE EFFECT OF PROPHYLACTIC MANAGEMENT AND THERAPEUTICS ON HYPERTENSIVE DISEASE IN PREGNANCY - PRELIMINARY STUDIES

  • 1 January 1981
    • journal article
    • research article
    • Vol. 57  (5) , 557-565
Abstract
A controlled prospective evaluation of pregnancy complicated by chronic hypertension is proposed and preliminary data on population selection and pregnancy outcome are presented. Sixty-three women with evidence of underlying hypertensive disease were followed prospectively throughout pregnancy. Twenty-three patients were followed in a protocol of intensified prenatal care and randomized assignment of antihypertensive agents: placebo, hydralazine, or methyldopa. Forty patients were followed in high-risk pregnancy clinics. The incidence of preeclampsia in the randomized prophylactic antihypertensive group was statistically lower than that in the nonrandomized group (8.7 vs. 32.5%; P < .01). There were no other statistically significant differences between the groups. The 63 hypertensive women had a high incidence of diabetes mellitus diagnosed during pregnancy (49.2%) as compared to the general obstetric population studied (8.1%).

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