HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+T cells
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- 21 April 2004
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 101 (18) , 7064-7069
- https://doi.org/10.1073/pnas.0401922101
Abstract
We recently reported that HLA-G1-transfected antigen-presenting cells (HLA-G1+APCs) were capable of inhibiting alloproliferative responses. The aim of the present work was to further study the function and the mechanisms of action of HLA-G1+APCs. We show here that HLA-G1+APCs are immunoinhibitory cells that (i) inhibit the proliferation of CD4+T cells, (ii) shed HLA-G1 molecules that might provide extra, non-antigen-specific, inhibitory or proapoptotic signals, (iii) induce CD4+T cell anergy, or at least long-term unresponsiveness, and (iv) cause the differentiation of CD4+T cells into suppressive cells. Thus, HLA-G+APCs might (i) be involved in the direct suppression of immune responses and (ii) contribute to long-term efficient immune escape or tolerance.Keywords
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