Kinetics of reactions in heterocycles. Part VIII. Preparation and reactivity of trimethylammonio derivatives of aza monocycles (pyridine and pyrimidine) towards hydroxide ion
- 1 January 1971
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society B: Physical Organic
- p. 1675-1682
- https://doi.org/10.1039/j29710001675
Abstract
Trimethylammonio-derivatives of pyridine, nitropyridine, pyrimidine, and nitropyrimidine have been prepared and the kinetics of their reactivity towards hydroxide ion have been measured. Pyrimidin-2-yltrimethylammonium chloride has been found to be ca. 700 times more reactive than 2-chloropyrimidine and ca. 5 times less reactive than 2-methylsulphonylpyrimidine, at 20°. Ionisation constants and u.v. and n.m.r. spectra are recorded and discussed.Keywords
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