Cis-trans Relationship between the Two Amino-acids Obtained by Hydrogenation of p-Aminomethyl Benzoic Acid.

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Abstract
In order to establish which of the two isomers of 1,4-aminomethyl-cyclohexane-carboxylic acid is the cis and which the trans form, the crystal structure of the hydrobromide of the amino-acid which is "inactive" as an anti-fibrinolytic agent has been determined. It was found that the inactive amino-acid is the cis isomer and consequently the "active" amino-acid the trans form. Details of the crystal structure of the hydro-bromide of the "inactive" amino-acid are presented.