Comparison of Myotrophic and Androgenic Activities of 19-Nortestosterone Cyclopentylpropionate, Androstanolone, and Methylandrostenediol

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Abstract
Three steroids with protein anabolic activity were tested in parallel with testosterone propionate to compare their relative properties of stimulating the levator ani muscles and seminal vesicles of weanling castrate male rats when injected subcutaneously in oil solution or suspension. The androgenic and myotropic potencies of the test compounds, as well as their myotropic/ androgenic ratios, were calculated by analysis of significant portions of the data. The androgenic potencies of these steroids, expressed as percentages of the potency of testosterone propionate, were: methylandrostenediol 2.1, androstanolone 13.2, 19-nortestosterone cyclopentylpropionate 16.2. The myotropic potencies, expressed as percentages of the potency of testosterone propionate, were: methylandrostenediol 2.2, androstanolone 21.8, 19-nortestosterone cyclopentylpropionate 155. The myotropic androgenic ratios of these compounds are, therefore: methylandrostenediol 1.0, andros tanolone 1.7, 19-nortestosterone cyclopentylpropionate 9.5.