HEMOLYTIC CRISIS IN HEREDITARY SPHEROCYTOSIS: STUDY OF A FAMILY OF FIVE WITH CONCURRENT CRISES

Abstract
Current literature on hemolytic crises in hereditary spherocytosis (congenital hemolytic jaundice) is briefly reviewed. The case histories of a family group of 5 who developed hemolytic crises at about the same time are reported. While reticulocytopenia and leukopenia with little or no jaundice occurred in these crises; serial detns. of fecal urobilinogen output on 2 cases suggested that acceleration of hemolysis played an important role in the pathogenesis of these hemolytic crises.