Coronary dilator effect of MCI-176, a new calcium channel blocker, in dogs.
- 1 January 1986
- journal article
- research article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 150 (1) , 101-102
- https://doi.org/10.1620/tjem.150.101
Abstract
Effects of MCI-176, 2-(2,5-dimethoxyphenylmethyl)-3-(2-dimethyl-aminoethyl)-6-isopropoxy-4 (3H)-quinazolinone hydrochloride, on coronary and aortic blood flows, mean blood pressure and heart rate were investigated in comparison withthose of diltiazem in anesthetized dogs. MCI-176, like diltiazem, dose-dependently increased coronary and aortic blood flows and decreased mean blood pressure. In producing these effect MCI-176 was slightly but significantly more potent than diltiazem. Heart rate tended to increase with MCI-176, whereas it tended to decrease with diltiazem.This publication has 0 references indexed in Scilit: