Rescue of the defective genome of Moloney sarcoma virus from a noninfectious hamster tumor and the production of pseudotype sarcoma viruses with various murine leukemia viruses.

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Abstract
A hamBter MSV [Moloney sarcoma virus]-induced rhabdomyosarcoma carried in vivo and in vitro was free of infectious virus and CF [complement-fixing] antigen. When the hamster tumor cells were grown in contact with mouse cells, either as mixed tissue cultures or by inoculation into newborn mice, in the presence of various murine leukemia virus strains focus-forming and sarcomagenic viruses were recovered. Preliminary studies indicate that the focus-forming viruses so recovered have the envelope antigens of the helper virus, and thus represent newly created pseudotypes of MSV.