Repression of Intracellular Virulence Factors in Salmonella by the Hha and YdgT Nucleoid-Associated Proteins
- 1 May 2007
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 189 (9) , 3669-3673
- https://doi.org/10.1128/jb.00002-07
Abstract
The Hha/YmoA family of nucleoid-associated proteins is involved in gene regulation in enterobacteria. In Salmonella enterica serovar Typhimurium, virulence genes required for intracellular growth are induced following host cell invasion but the proteins responsible for repressing these genes prior to host cell entry have not been fully identified. We demonstrate here that Hha is the major repressor responsible for silencing virulence genes carried in Salmonella pathogenicity island 2 prior to bacteria sensing an intracellular environmental cue.Keywords
This publication has 25 references indexed in Scilit:
- H-NS Mediates the Silencing of Laterally Acquired Genes in BacteriaPLoS Pathogens, 2006
- Selective Silencing of Foreign DNA with Low GC Content by the H-NS Protein in SalmonellaScience, 2006
- Salmonella Pathogenicity Island 2 Is Expressed Prior to Penetrating the IntestinePLoS Pathogens, 2005
- The PhoP/PhoQ system controls the intramacrophage type three secretion system of Salmonella entericaMolecular Microbiology, 2005
- YdgT, the Hha paralogue in Escherichia coli, forms heteromeric complexes with H‐NS and StpAMolecular Microbiology, 2004
- YmoA Negatively Regulates Expression of Invasin fromYersiniaenterocoliticaJournal of Bacteriology, 2003
- Evidence for Direct Protein-Protein Interaction between Members of the Enterobacterial Hha/YmoA and H-NS Families of ProteinsJournal of Bacteriology, 2002
- Hha Is a Negative Modulator of Transcription ofhilA, theSalmonella entericaSerovar Typhimurium Invasion Gene Transcriptional ActivatorJournal of Bacteriology, 2001
- The hha gene modulates haemolysin expression in Escherichia coliMolecular Microbiology, 1991
- ymoA, a Yersinia enterocolitica chromosomal gene modulating the expression of virulence functionsMolecular Microbiology, 1991