Gene transfer by means of cell fusion: II the mapping of 8 loci on human chromosome 1.by statistical analysis of gene assortment in somatic cell hybrids

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Abstract
A method is described which should permit determination of the order and spacing of genes on all human chromosomes by the analysis of just one set of man-mouse hybrid cells. This method is used to determine the map of 8 loci on human chromosome 1. A comparison of the statistical maps of chromosome 1 and of the X-chromosome with the cytogenetic maps of these chromosomes at metaphase indicates that the statistically derived distances between genes are related to the amount of Giemsa light-band material between the genes.