Comparison of dose-time–fractionation schemes in non-oat cell lung cancer

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Abstract
A series of 205 patients with inoperable, non‐oat cell carcinoma of the lung were treated with three different dose‐fractionation schedules. Fifty‐six patients received 5000 rads in 25 fractions over five weeks (continuous, A); 79 patients received 2000 rads in five fractions over five days, with two weeks' rest, followed by 2000 rads in five fractions over five days (split‐course, B); 70 patients received 3000 rads in 10 fractions over two weeks, followed by three weeks' rest and another 3000 rads (split‐course, C). The 24‐month survival was 33% for A, 15% for B and 25% for C. The split course was better tolerated and radiation fibrosis was dose‐related.