SIALIC-ACID CONTENT AND GROWTH-CONTROL OF MOUSE CELLS TRANSFORMED BY A TEMPERATURE-SENSITIVE MUTANT OF SV40
- 1 January 1978
- journal article
- research article
- Vol. 9 (6) , 503-510
Abstract
The sialic acid content of mouse cells transformed by a temperature-sensitive (ts) mutants of SV-40 was derived from changes in the sialic acid content in the plasma membrance which resulted from changes in the microsomal sialytransferase activity. Plasma membrane glycoproteins of ts-mutant transformed cells showed significantly different patterns on electrofocusing, but when treated with neuraminidase, differences of elution patterns were extinguished. There was a positive correlation between sialic acid content and loss of contact inhibition in the cell line examined.This publication has 4 references indexed in Scilit:
- Alterations in surface glycoproteins and level of sialyltransferase of cells transformed by a temperature-sensitive mutant of simian virus 40.Proceedings of the National Academy of Sciences, 1976
- Glycolipids of hamster fibroblasts and derived malignant-transformed cell lines.Proceedings of the National Academy of Sciences, 1968
- The Contribution of Sialic Acid to the Surface Charge of the ErythrocyteJournal of Biological Chemistry, 1962
- The Thiobarbituric Acid Assay of Sialic AcidsJournal of Biological Chemistry, 1959