Chemistry of Thyroxine

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Abstract
The authors describe the synthesis of thyroxine from 3:5 diiodo-4-(4[image]- me-thoxy-phenoxy) nitro benzene, [image] carrying the procedure through 11 steps to the final [beta]-[3:5-diiodo-4-(3[image]:5[image]-diiodo-4[image]-hydroxyphenoxy)] phenyl-[alpha]-aminopropionic acid, [image] CH(NH2)[center dot]COOH. The final product is regarded as identical, in its chemical and physiological properties, with thyroxine isolated from the thyroid gland. The synthesis of the I-containing degradation product of thyroxine offers confirmatory evidence by which they regard the constitution of thyroxine as finally established. The effect of the synthetic thyroxine in raising the basal metabolic rate is quantitatively similar to that of natural thyroxine.

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