Cytophilic Immunoglobulin Responses toPlasmodium falciparumGlutamate-Rich Protein Are Correlated with Protection against Clinical Malaria in Dielmo, Senegal
Open Access
- 1 May 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (5) , 2617-2620
- https://doi.org/10.1128/iai.68.5.2617-2620.2000
Abstract
The goal of this study was to analyze antibody responses toPlasmodium falciparumglutamate-rich protein (GLURP) using clinical data and plasma samples obtained from villagers of Dielmo, Senegal. This molecule was chosen because it is targeted by human antibodies which induce parasite growth inhibition in antibody-dependent cellular inhibition (ADCI) assays. The results showed a strong correlation between protection against malaria attacks and levels of immunoglobulin G2 (IgG2) and IgG3 against GLURP94–489(R0) and IgG3 against GLURP705–1178(R2) when corrected for the confounding effect of age-related exposure to malaria. Thus, GLURP may play a role in the induction of protective immunity againstP. falciparummalaria.Keywords
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