Catalytic Antibodies: A New Window on Protein Chemistry
- 28 September 2007
- book chapter
- Published by Wiley
- Vol. 159, 201-210
- https://doi.org/10.1002/9780470514108.ch14
Abstract
A review with 10 refs. Catalytic antibodies have created a new dimension in protein chem. In these studies it is particularly valuable to investigate systems for which natural enzymic catalysts are unknown. Several ways of prepg. homochiral building blocks for org. synthesis have been examd. by the authors. Antibodies that catalyze the Diels-Alder reaction have been characterized. The target reaction was the addn. of acetoxybutadiene to N-substituted maleimides, a reaction that should give a pentafunctional homochiral building block. Catalytic antibodies can give insight into the mechanism of catalysis by proteins. An adventitious hydrolytic antibody that cleaves activated esters was investigated. An antibody raised to ampicillin for anal. purposes has also been shown to catalyze hydrolysis of the β-lactam ringKeywords
This publication has 9 references indexed in Scilit:
- Selectivity in synthesis — chemicals or enzymes?Published by Springer Nature ,1990
- Bait and switch strategy for obtaining catalytic antibodies with acyl-transfer capabilitiesJournal of the American Chemical Society, 1990
- Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage LambdaScience, 1989
- Antibody catalysis of the Diels-Alder reactionJournal of the American Chemical Society, 1989
- Catalytic Antibodies with Lipase Activity and R or S Substrate SelectivityScience, 1989
- A new strategy for the generation of catalytic antibodiesNature, 1989
- A Stereospecific Cyclization Catalyzed by an AntibodyScience, 1987
- The STO-3G transition structure of the diels-alder reactionTetrahedron Letters, 1984
- The Total Synthesis of Steroids1Journal of the American Chemical Society, 1952